You can pick up your rental car in the US at the airport or after your visit New York City. In the city itself, you are better off using the inexpensive subway and bus facilities. Within New York City/Manhattan, there are several locations where car rentals are available. Car rental is relatively inexpensive in the US. Check the website for the attractive rates. From here, you can travel south, for example via Washington DC, Atlanta, or Florida. We suggest that you visit the Kennedy Space Center, while you still can, for a stunning overview of US space history. Return the car to any international airport of your choice. With Avis, this is an option at almost every airport in the US.